Que significa "Clear"?
O animal non leva a mutación. Non desenvolverá a enfermidade e non o transmitirá.
Can Resistencia a múltiples fármacos 1 (MDR1)
The Multidrug Resistance 1 (MDR1) DNA test in dogs is essential for identifying genetic mutations that affect drug sensitivity. This test helps veterinarians and pet owners prevent adverse reactions to common medications by detecting the MDR1 gene mutation. Dogs with this mutation may experience severe side effects from certain drugs, making early detection crucial for safe treatment. Popular breeds like Collies, Australian Shepherds, and Border Collies are often tested for MDR1. By using the MDR1 DNA test, you can ensure personalized and safer veterinary care for your dog. Protect your pet’s health by understanding their genetic makeup today. Stay informed and avoid harmful drug reactions with the MDR1 test.
Abreviatura: MDR1
Mutación analizada: ABCB1 c.228_231del
Herdanza: Autosómico dominante
Acrónimo
MDR1
Frecuencia observada
Gravidade clínica
Clasificación clínica
Enfermidades Toxicolóxicas
Mutación analizada
ABCB1 c.228_231del
p.(D77Afs*16)
p.(D77Afs*16)
Modo de herdanza
Autosómico dominante (Incompleto)
Resumo da proba:
The Multidrug Resistance 1 (MDR1) DNA test in dogs identifies a genetic mutation that affects drug sensitivity. Dogs with this mutation may have adverse reactions to certain medications, including common dewormers and chemotherapy drugs. Testing helps veterinarians choose safe and effective treatments tailored to the dog's genetic profile. It is especially important for breeds like Collies, Australian Shepherds, and Border Collies, which are more prone to the mutation. Early detection through the MDR1 test can prevent harmful side effects and improve overall pet health care.
Dispoñible no pack: Basic
Esta proba de ADN está incluída a partir do noso paquete Basic — e tamén forma parte dos paquetes Basic, Standard, Advanced, Complete.
Ver paquetes de probas de ADN →Elixe o paquete que mellor se adapta á túa estratexia de reprodución ou saúde dos teus animais.
Introduction to MDR1 in Dogs
Multidrug Resistance 1 (MDR1) is a genetic condition in dogs that affects the function of the blood-brain barrier and the ability to process certain medications. This condition is caused by a mutation in the ABCB1 gene, which is responsible for encoding a protein that pumps drugs out of the brain to protect it from potentially harmful substances. When this gene is mutated, the efficiency of this protective mechanism is compromised, leading to increased sensitivity to a range of medications.
Significance of the MDR1 Mutation
The MDR1 mutation is particularly significant because it can affect how dogs respond to various drugs, including some commonly used in veterinary medicine. Dogs with this mutation may experience severe adverse reactions to certain medications, which can lead to potentially life-threatening situations. Understanding whether a dog carries this mutation is crucial for veterinarians when prescribing medications, as it directly influences treatment choices and dosages.
Common Medications Affected by MDR1
Several medications are known to interact negatively with the MDR1 mutation. These include, but are not limited to, drugs such as ivermectin (often used for heartworm prevention), certain anti-cancer drugs, and some pain medications. When administered to dogs with the MDR1 mutation, these drugs can lead to neurological signs such as tremors, seizures, and even coma. Therefore, awareness of this condition is essential for proper veterinary care.
Clinical Signs of MDR1 Mutation
Dogs that have the MDR1 mutation may exhibit various clinical signs when exposed to drugs that they cannot properly process. Symptoms can include lethargy, incoordination, hypersalivation, vomiting, and seizures. The severity of these reactions can vary based on the dosage and the specific drug involved. It is important for pet owners to monitor their dogs closely for any adverse effects following medication administration and to consult their veterinarian promptly if any concerning symptoms arise.
Management and Treatment Strategies
Management of dogs with the MDR1 mutation primarily involves avoiding the use of certain drugs that could trigger adverse reactions. Veterinarians can recommend alternative medications that are safe for dogs with this genetic condition. It is also advisable for pet owners to inform all veterinary professionals involved in their dog’s care about the MDR1 status, ensuring that all treatments are tailored to the dog’s specific needs.
Conclusión
The MDR1 mutation is an important genetic condition that can significantly impact a dog's health and treatment options. Understanding this mutation allows veterinarians to provide safer, more effective care for affected dogs. Pet owners are encouraged to consider DNA testing for MDR1, especially if their dog is at risk, to ensure that they can avoid potentially harmful medications and manage their pet's health proactively.
Raza recoñecida para a proba: Resistencia a múltiples fármacos 1 (MDR1)
- American White Shepherd Dog
- Aussiedoodle
- Australian Koolie
- Australian Shepherd
- Australian Stumpy Tail Cattle Dog
- Austrian Standard Pinscher
- Bearded Collie
- Bernedoodle
- Blue Heeler
- Border Collie
- Bordoodle
- Brussels, Standard Griffon
- Carolina Dog
- Cavapoo
- Cavapoochon
- Chinook
- Cockapoo
- Danish–Swedish farmdog
- Danoodle
- English Shepherd
- Farm Collie
- German Shepherd Dog
- Goldendoodle
- Irishdoodle
- Koolie
- Labradoodle
- Long-Haired Whippet
- Maltipoo
- McNab Shepherd
- Miniature American Shepherd
- Miniature Australian Shepherd Dog
- Miniature Poodle
- Newfypoo
- Old English Sheepdog
- Old Farm Collie
- Poodle
- Rough Collie
- Schnoodle
- Scottish Collie
- Scottish Rough Collie
- Scottish Smooth Collie
- Serbian Balkan Standard Hound
- Sheepadoodle
- Shetland Sheepdog
- Shiloh Shepherd
- Silken Windhound
- Smooth Collie
- Swiss White Shepherd Dog
- Toy Australian Shepherd Dog
- Toy Poodle
- Waller
- Working Kelpie
- Yorkiepoo
🧬 Interpretation of genotypes MDR1
Xenotipo
Estado
🟡 N/N
Non transportista - Sen risco
🟡 N/MDR1
Transportista - En risco
❌ MDR1/MDR1
Afectado - En risco
FAQ: entender a interpretación
Un "Carrier" é serio?
Non. O animal é xeralmente san pero pode transmitirlle a mutación descendencia.
E se un animal está "afectado"?
Leva dúas copias mutadas. Espéranse signos clínicos dependendo de a enfermidade. Non se debe criar.
Por que hai diferenzas entre homes e mulleres?
Algunhas enfermidades están ligadas ao sexo, polo que a súa expresión varía dependendo da sexo animal.
Predicir a descendencia
N/N (non-transportista)
N/MDR1 (Transportista)
MDR1/MDR1 (Afectado)
Preguntas frecuentes sobre as probas de ADN
Que detecta esta proba de ADN?
This DNA test detects the mutation associated with Multidrug Resistance 1 (MDR1) in order to identify clear, carrier, or at-risk animals.
Por que probar un animal de cría?
As probas de ADN axudan aos criadores a planificar apareamentos máis seguros e a reducir o risco de transmitir a mutación á descendencia.
Cal é o modo de herdanza desta proba?
O modo de herdanza informado para esta proba é autosómico dominante.
Que mutación se analiza nesta proba?
This test analyses the mutation ABCB1 c.228_231del.
Un animal portador está necesariamente afectado?
Non necesariamente. A interpretación depende do patrón de herdanza e do xenotipo resultante.
Referencias
Mealey K L, Bentjen S A, Gay J M, Cantor G H. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics. 2001 Nov;11(8):727-33. doi: 10.1097/00008571-200111000-00012.