Horse Splashed White SW2 (SW2)

The Splashed White SW2 (SW2) DNA test is essential for horse breeders and enthusiasts aiming to identify this unique coat pattern gene. This genetic marker causes distinctive white markings, often characterized by a splashed appearance on the horse’s body, face, and legs. By using the SW2 DNA test, breeders can predict and select for this striking coat color in their breeding programs. Understanding the presence of the SW2 gene helps improve breeding decisions and enhances the value of horses with rare and desirable patterns. Accurate DNA testing ensures responsible breeding and supports the preservation of the Splashed White phenotype. Trust reliable laboratories for precise SW2 genetic analysis. Stay informed and elevate your breeding strategy with the Splashed White SW2 DNA test.

Abbreviation : SW2

Analysed mutation : PAX3 c.209G/A

Inheritance : Autosomal Dominant

Acronym

SW2

Observed frequency

Normal

Clinical classification

Coat-Related Traits

Analysed mutation

PAX3 c.209G/A
p.(C70Y)

Mode of inheritance

Autosomal Dominant (Incomplete)

Test summary:

The Splashed White SW2 (SW2) DNA test identifies a specific genetic variant responsible for the Splashed White coat pattern in horses. This pattern is characterized by white markings that appear as if the horse has been dipped in white paint, often with blue eyes. The SW2 gene mutation affects the migration of pigment cells during development. Testing for SW2 helps breeders predict coat colors and avoid potential health issues linked to the gene. Understanding this genetic marker supports informed breeding decisions and enhances appreciation of equine coat diversity.

Available from the pack : Standard

This DNA test is included starting from our pack Standard — and is also part of the packs Standard, Advanced, Complete.

View DNA Test Packs →

Choose the pack that best fits your breeding or health strategy of your animals.

Understanding Splashed White SW2 in Horses

Splashed White SW2 (SW2) is a genetic condition that affects the coat color of horses, resulting in a distinctive pattern characterized by large, irregular white markings. This condition is part of a group of genetic variations that influence pigmentation and patterning in equine coat colors.

Genetic Basis of Splashed White SW2

The Splashed White SW2 pattern is caused by mutations in specific genes responsible for pigment production in the skin and hair. These mutations can disrupt the normal distribution of pigment cells, leading to the characteristic white patches that define this coat pattern. The condition is inherited in an autosomal dominant manner, meaning that only one copy of the mutant gene is required for the phenotype to be expressed.

Characteristics of the Splashed White SW2 Pattern

Horses with the SW2 pattern typically exhibit white markings that can cover varying degrees of their body. These markings often include a white face and lower limbs, with the potential for additional white patches on the body. The extent and distribution of the white areas can vary significantly between individuals, making each SW2 horse unique in appearance.

Health Implications Associated with SW2

While the primary focus of the SW2 condition is its visual impact on coat color, it is essential to understand that it can be associated with certain health issues. Some horses with the SW2 pattern may be predisposed to deafness or other sensory impairments due to the underlying genetic mutations. Regular veterinary check-ups and monitoring for any health concerns are advisable for horses displaying this coat pattern.

Breeding Considerations for Splashed White SW2

When considering breeding horses with the SW2 pattern, it is crucial for breeders to be aware of the genetic implications of this condition. Breeding two SW2 individuals can increase the likelihood of producing offspring with more severe color patterns or health issues. Therefore, genetic testing and careful selection of breeding pairs are essential to minimize potential complications and maintain the health and viability of future generations.

Conclusion

The Splashed White SW2 coat pattern is a fascinating aspect of equine genetics that showcases the diversity of horse colors and markings. Understanding the genetic basis, health implications, and breeding considerations associated with SW2 can help horse owners and breeders make informed decisions while appreciating the unique beauty of these horses.

Breed recognized for the test : Splashed White SW2 (SW2)

Lipizzan horse
Noric
Quarter Horse

Interpretation of genotypes Genotype Status Learn more about the interpretation of genotypes FAQ: understanding the interpretation of result What does “Clear” mean? The animal does not carry the mutation. It will not develop the disease and will not pass it on. Is a “Carrier” serious? No. The animal is generally healthy but can transmit the mutation to its offspring. What if an animal is “Affected”? It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred. Why are there differences between male / female? Some diseases are sex-linked, so their expression varies depending on the animal’s sex. The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

🧬 Interpretation of genotypes SW2

Genotype

Status

🟡 N/N

Non-carrier - No effect

🟡 N/SW2

Carrier - Splashed White

❌ SW2/SW2

Affected - Splashed White

FAQ: understanding the interpretation

What does “Clear” mean?

The animal does not carry the mutation. It will not develop the disease and will not pass it on.

Is a “Carrier” serious?

No. The animal is generally healthy but can transmit the mutation to its offspring.

What if an animal is “Affected”?

It carries two mutated copies. Clinical signs are expected depending on the disease. It should not be bred.

Why are there differences between male / female?

Some diseases are sex-linked, so their expression varies depending on the animal’s sex.

Genotype Forecast for Offspring Mother Father Non-carrier Carrier Affected Favorable cross: majority Carrier risk is predominant. Majority affected Filter by mother's genotype Filter by father's genotype All Predict Offspring The animal has two normal copies of the gene. No risk of developing or transmitting the disease. Heterozygous carrier: one mutated copy. The animal is usually not clinically affected but can pass the mutation to offspring. Male carrier or affected depending on the inheritance mode. Males have only one X or Y chromosome. Heterozygous female carrier: one mutated copy. She can pass the mutation on and may sometimes show mild clinical signs depending on the condition. Two mutated copies of the gene. The animal is at risk of developing the associated condition.

Predict Offspring

Filter by mother's genotype Filter by father's genotype

N/N (Non-carrier)

N/SW2 (Carrier)

SW2/SW2 (Affected)

DNA Test FAQ

What does this DNA test detect?

This DNA test detects the mutation associated with Splashed White SW2 (SW2) in order to identify clear, carrier, or at-risk animals.

Why test a breeding animal?

DNA testing helps breeders plan safer matings and reduce the risk of transmitting the mutation to offspring.

What is the inheritance mode of this test?

The inheritance mode reported for this test is Autosomal Dominant.

Which mutation is analysed in this test?

This test analyses the mutation PAX3 c.209G/A.

Is a carrier animal necessarily affected?

Not necessarily. Interpretation depends on the inheritance pattern and the resulting genotype.

References

Hauswirth Regula, Haase Bianca, Blatter Marlis, Brooks Samantha A, Burger Dominik, Drögemüller Cord, Gerber Vincent, Henke Diana, Janda Jozef, Jude Rony, Magdesian K Gary, Matthews Jacqueline M, Poncet PierreAndré, Svansson Vilhjálmur, Tozaki Teruaki, WilkinsonWhite Lorna, Penedo M Cecilia T, Rieder Stefan, Leeb Tosso. Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses. PLoS Genet. 2012;8(4):e1002653. doi: 10.1371/journal.pgen.1002653. Epub 2012 Apr 12.

My DNA Portal